One of the most serious potential side effects of chemotherapy is neutropenia (a low white blood cell count).<\/strong><\/p>\n As the chemotherapy destroys cancer cells, it may also destroy white blood cells. These cells are the body’s main defense against infection.<\/p>\n Because severe neutropenia often shortens and\/or delays treatment and requires hospitalization, reducing myelosuppression would allow for better outcomes from chemotherapy. (1)<\/em><\/p>\n Supplementation of fermented wheat germ extract (Metatrol Pro<\/a>, Avemar<\/a>)(2)<\/em> in pediatric cancer patients reduced incidence of febrile neutropenic episodes (24.8%) versus (43.4%) in the control group.<\/p>\n Protectival\u2122<\/a> (clinical trial name: LCS101) by LifeBiotic is an extract from 14 different\u00a0bioactive botanicals.<\/p>\n LCS101 was developed based on the principles of Chinese herbal medicine.<\/p>\n LCS101 consists of a mixture of varying quantities of dry powdered extracts of the following Chinese medicinal herbs: Astragalus membranaceus; Atractylodes macrocephala; Citrus reticulate; Glehnia littoralis; Ligustrum lucidum; Lycium chinense; Milletia reticulate; Oldenlandia diffusa; Ophiopogon japonicus; Paeonia lactiflora; Paeonia obovata; Poriae cocos; Prunella vulgaris; and Scutellaria barbata<\/em>.<\/p>\n In addition to the vast body of scientific evidence regarding these ingredients and their therapeutic effects, Protectival was subjected to rigorous testing, including a randomized, controlled, double blind clinical study in breast cancer patients receiving chemotherapy. (7)<\/em><\/p>\n The study concluded that adding LCS101 to anthracycline- and taxane-based chemotherapy is safe and well tolerated, and may significantly prevent chemotherapy-induced hematological toxicities.<\/strong><\/p>\n [sc name=”squareone2″]<\/p>\n Mushrooms have been used for at least 5000 years for nutritional and medicinal purposes.<\/p>\n Six components of these mushrooms have been investigated for their activity in human cancers: the lentinan component of shiitake<\/a>, schizophyllan, active hexose correlated compound (AHCC<\/a>), maitake<\/a> D-fraction and two components of Coriolus<\/a> (Trametes) versicolor (Turkey Tail) (8, 9, 10, 11).<\/em><\/p>\n Mushrooms are reported to have antimicrobial, anti-inflammatory, cardiovascular-protective, antidiabetic, hepatoprotective, and anticancer properties.<\/p>\n It is well-established that mushrooms are adept at immune modulation and affect hematopoietic stem cells, lymphocytes, macrophages, T cells, dendritic cells (DCs), and natural killer (NK) cells. (12)<\/em><\/p>\n Extensive research over the last 40 years has demonstrated that mushrooms have potent antineoplastic properties that slow growth of tumors, regulate tumor genes, decrease tumoral angioneogenesis, and increase malignant-cell phagocytosis.<\/p>\n Additionally, evidence suggests that medicinal mushrooms may safely boost chemotherapeutic efficacy and simultaneously protect against bone marrow suppression.<\/u><\/strong><\/p>\n A phase 1 clinical trial of Trametes versicolor<\/a> in women with breast cancer reported increased lymphocyte counts, increased natural killer cell functional activity and dose-related increases in CD8(+) T cells and CD19(+) B cells. The study concluded that the Turkey Tail preparation may improve immune status in immunocompromised breast cancer patients following standard primary oncologic treatment. (13)<\/em><\/p>\n Turkey Tail <\/a>mushroom is so widely used, it accounts for 25% of cancer care cost in Japan!<\/p>\n MD Anderson has a very comprehensive review of Coriolus versicolor<\/a> that is worth reading in its entirety. (14)<\/em><\/p>\n Another study examined the effect of the MD-fraction<\/strong> from the maitake<\/a> mushroom on cisplatin-induced myelosuppression in a mouse model. Mice given 8 mg\/kg\/d while treated with cisplatin did not experience a decrease in NK cells, DCs, and macrophages. (15)<\/em><\/p>\n Another study demonstrated that mice that had been immunosuppressed with cyclophosphamide and then subsequently treated with a water-soluble extract from reishi<\/a> had an increase in red blood cells (RBCs), white blood cells (WBCs), NK T cells, splenic NK cells, and a number of bone marrow cells. (16)<\/em><\/p>\n Melatonin supplements<\/a> (10 mg a day) improve immune function in patients suffering from a variety of cancers, including gastric, renal, prostate, and bladder cancers, without any apparent adverse effects. (17)<\/em><\/p>\n Clinical studies support melatonin\u2019s value, demonstrating that supplements of 20 mg a day can improve immune function in cancer patients, predominantly by enhancing the immunity driven by the two chief anti-tumor messengers, interleukin-2 and interleukin-12 (18)<\/em><\/p>\n Bacterial translocation via intestinal mucosa is a significant mechanism of febrile neutropenia development. Competitive inhibition of bowel colonization by pathogenic microorganisms by lactic acid bacteria (probiotics<\/a>) could be a useful prophylaxis for neutropenia.<\/p>\n Your doctor may also prescribe a granulocyte colony-stimulating factor<\/strong> (G-CSF) such as NEUPOGEN (filgrastim). NEUPOGEN\u00ae (filgrastim) is indicated to decrease the incidence of infection\u201a as manifested by febrile neutropenia\u201a in patients with nonmyeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a significant incidence of severe neutropenia with fever.<\/p>\n Parents of children with neuroblastoma may be advised to exercise caution here as there is some evidence<\/a> to suggest that G-CSF could actually stimulate existing cancer.<\/p>\n Naturally Manage Chemotherapy Induced Mucositis<\/a><\/p>\n Naturally Manage Chemotherapy Induced Cachexia (Weight Loss) and Hair Loss<\/a><\/p>\n Naturally Mitigate Neuropathy and Other Vincristine Side Effects<\/a><\/p>\n Applying Integrative Childhood Cancer Therapies<\/a><\/p>\n Evidence Based Integrative Approaches for Childhood Cancer: Audra & Justin Wilford of MaxLove Project<\/a><\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" Managing Leukopenia \/ Neutropenia One of the most serious potential side effects of chemotherapy is neutropenia (a low white blood cell count). As the chemotherapy destroys cancer cells, it may also destroy white blood cells. These cells are the body’s main defense against infection. Because severe neutropenia often shortens and\/or delays treatment and requires hospitalization, […]<\/p>\n","protected":false},"author":5,"featured_media":3429,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[193,132,194,131],"_links":{"self":[{"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/posts\/3006"}],"collection":[{"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/comments?post=3006"}],"version-history":[{"count":0,"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/posts\/3006\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/thesternmethod.com\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/media?parent=3006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/categories?post=3006"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thesternmethod.com\/wp-json\/wp\/v2\/tags?post=3006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Supplements That May Help Manage Leukopenia \/ Neutropenia<\/h3>\n
Metatrol Pro, Avemar<\/h4>\n
Other things to consider include selenium<\/a>, astragalus<\/a> (3, 4)<\/em>, shark liver alkylglycerols<\/a>, Protectival<\/a> (5, 6)<\/em>, melatonin<\/a>, medicinal mushrooms (see below) and\/or probiotics<\/a>.<\/h4>\n
Protectival\u2122<\/h4>\n
Mushrooms<\/h4>\n
Melatonin<\/h4>\n
Probiotics<\/h4>\n
You may also be interested in:<\/h4>\n
\nResources:<\/h5>\n
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