[00:00:00] Latest and Greatest in Dr. Isaac Eliaz’s World Regarding Health and Wellness: The Power of the Mind in Healing Chronic Disease

[00:06:40] Introducing the Survival Paradox: A Holistic Approach to Cancer and Chronic Disease

[00:09:22] The Survival Paradox: Galectin-3 and Its Role in Cancer and Chronic Disease

[00:14:55] The Role of Galectin-3 in Cancer Metastasis and Immune Suppression

[00:16:22] The Widespread Impact of Galectin-3 on Chronic Diseases and Its Role in Inflammation

[00:17:16] Galectin-3’s Role in Cancer, Inflammation, and Systemic Disease Progression

[00:24:49] Blocking Galectin-3 with Modified Citrus Pectin: A Solution for Cancer and Chronic Disease

[00:26:14] How Modified Citrus Pectin (MCP) Reactivates Immune Response Against Cancer

[00:27:18] The Unique Absorption and Systemic Benefits of Modified Citrus Pectin (MCP)

[00:28:59] The Synergistic Role of Modified Citrus Pectin (MCP) in Cancer Treatment and Support

[00:30:58] Using Modified Citrus Pectin (MCP) to Reduce Cancer Spread Risks During Biopsy and Surgery

[00:32:18] Clinical Success of Modified Citrus Pectin (MCP) in Slowing Cancer Growth and Enhancing Immune Response

[00:37:13] The Wide-Ranging Health Benefits of Modified Citrus Pectin (MCP) Beyond Cancer Treatment

[00:38:15] Dosage Recommendations for Modified Citrus Pectin (MCP) Based on Health Needs

[00:39:30] Honokiol: A Powerful Compound for Oncology and Neurological Health

[00:41:40] Honokiol’s Role in Cellular Energy Regulation and Its Synergy with MCP in Cancer Cells

[00:45:23] Honokiol’s Adaptive Role in Cancer Treatment: Regulating Cellular Metabolism and Enhancing Therapies

[00:46:10] Synergy of Honokiol and MCP: Supporting Oncology, Inflammation, and Neurological Health

[00:47:44] Dosage Guidelines for Honokiol and MCP: Supporting Sleep, Anxiety, Inflammation, and Cancer

[00:49:01] Transforming the Survival Drive: Galectin-3 Blockers, Detox, and Open-Heart Meditation for Healing

[00:54:12] Supporting Chronic Lymphocytic Leukemia (CLL) with MCP, Honokiol, and Detox Strategies

[00:56:35] MCP and Honokiol Dosage Guidelines for Children and Support for Cancers Like CLL and Multiple Myeloma

[00:59:23] Supporting Neurodegenerative Diseases with MCP, Honokiol, GlyphoDetox, and Additional Therapies

[01:01:24] Tips for Properly Dissolving MCP and Combining It with Other Supplements

[01:03:27] Timing MCP and Other Supplements with Thyroid Medication

[01:04:00] Galectin-3 Testing: Availability, Interpretation, and Its Role as a Health Biomarker

[01:08:04] Low Galectin-3 Levels: Rare Cases in Cancer and the Impact on Fibrosis and Immune Response

[01:09:45] Using MCP for Smoldering Multiple Myeloma and Its Long-Term Benefits in Detoxification and Immune Support

[01:12:00] The Power of Positive Language and Long-Term Integrative Support in Cancer Remission

[01:16:59] MCP for Hormone-Positive Breast Cancer and Its Synergy with Hormonal Therapies

[01:18:30] Combining Pectosol with Other Supplements: No Interference with Mineral Levels

[01:18:58] Supporting Vasculitis with Pectosol, Honokiol, and Detoxification

[01:19:53] Post-Radiation Support for Throat Cancer: Preventing Scarring and Enhancing Treatment with MCP and Honokiol

[01:23:10] PQQ and Shilajit: Supporting Gut Health, Detox, and Mitochondrial Function

[01:23:50] MCP as Nutritional Support for Lyme Disease: Enhancing Antibiotic Effectiveness and Reducing Inflammation

[01:24:42] Using Artemisinin for Prostate Cancer: Dosage Guidelines and Liver Health Monitoring

[01:25:48] Supporting Kidney Health and Managing Blood in Urine Post-Injury with MCP: Dosage Guidelines for Kidney Function

[01:27:09] Supporting Glioblastoma Treatment with Honokiol, MCP, and Detoxification

[01:28:00] Managing Mold Toxicity with MCP, GlyphoDetox, and Gradual Detoxification

[00:00:00] Latest and Greatest in Dr. Isaac Eliaz’s World Regarding Health and Wellness: The Power of the Mind in Healing Chronic Disease

Ryan Sternagel: Dr. Elias, the traditional first question as folks are logging on: you are a doctor who knows a lot about chronic disease—let’s put it that way. You’re not allowed to talk about Pectosol or hone up here because that’s what we’re going to be discussing this whole time. But, random question: when I say “healing from chronic disease,” what’s the latest thing you’ve been working on or thinking about? What popped into your head this morning when you were taking a shower, or what comes to mind right now when I say “healing from chronic disease”—but no talking about your three or one of your products!

Dr. Isaac Eliaz: I think the thing that’s been inspiring me, part of my training, is recognizing the power that our mind has to heal from anything. It’s not a blanket, random statement, or journalistic phrase. I’ve trained in this for decades all over the world, including having the privilege of being the doctor and private student of some of the greatest meditation masters in the Himalayas.

I’ve seen things I cannot believe, things we cannot explain with science; We can’t. While I am a solid scientist, working with NIH grants, I think the power of the mind—especially the heart—to heal anything is important to recognize. When we recognize this, we stop putting conceptual limitations on what is possible. It not only affects the outcome of chronic disease, but it also affects the quality of our lives; It changes our possibilities. Our possibilities are endless because everything is changeable; The only thing that limits them is our concepts, our belief systems, and our limitations. Some of them are ours, and some are projected onto us by family, friends, or even Western medicine, which can do a lot of good but is limited to a certain paradigm.

The idea is to throw away the concept of “thinking outside the box” because there was never a box to begin with.

Ryan Sternagel: Oh, there you go.

Dr. Isaac Eliaz: This is how I’ll start. We’ve pretty much ended the conversation already; now we pick up on the details.

Ryan Sternagel: You put that well earlier that it’s not just understanding conceptually because that’s easy. I’ve understood that conceptually, theoretically, hypothetically—whatever you want to call it—for quite some time now, but diving in and knowing it is a whole different thing entirely. Jesus was talking about it 2,000 years ago, saying, “All things are possible to him that believes.” “He that believeth on me, the works that I do, shall he do also.” It wasn’t just about Him; it was about believing like He believed—like anything is possible.

Dr. Isaac Eliaz: This is how miracles happen. Miracles are things that are not expected, and what’s expected is based on our habits. When we throw out our habits, the possibilities become very different. You see this in many traditions, a lot of them from around the same historical time. It’s very fascinating.

Ryan Sternagel: Dr. Elias, I realize I don’t have your bio pulled up. I should have done that.

Dr. Isaac Eliaz: I have a little bit here.

Ryan Sternagel: Give me the informal version.

Dr. Isaac Eliaz: When I started my presentation, I had my stuff prepared. Oh, you’ve got it all there, I know it.

Ryan Sternagel: That being said, let’s jump into it. One quick note—this talk about the “woo” power of the mind stuff is synchronistic. I just got off our Going Integrative Plus member call, and for anybody interested, Dr. Elias is going to be on that next week, I think. It’s a very cancer-focused call, where members get to ask anything they want for a couple of hours on all things cancer. It’s the resource that my wife and I would have given anything for when our son was going through it.

We had Dr. Marisol Teijero (I can never say her name right) on the call. Somebody asked about fermented wheat germ extract, and what she thought about it. Somehow her answer turned out to be, “It’s expensive, and I like modified citrus pectin better.” That was one of the last questions and answers we had on that call. Then she went off on how much she loves modified citrus pectin, how she gives it to all her patients, and all this stuff. I thought that was a pretty neat segue into what we’re doing here today—a random, neat thing.

Dr. Isaac Eliaz: It is. And by the way, that’s happening all the time now, because the secret is out. It was kept quiet for a while—I was too busy. But now it’s time to share it with the world.

Ryan Sternagel: I’m glad that I went to all those conferences early on, even before we were doing the official online thing, trying to learn everything we could for our son and whatnot. I found out about you a long time before the rest of the world did. Anyway, let’s jump into it. Do you have slides and whatnot?

Dr. Isaac Eliaz: Yes, I do. I can share.

[00:06:40] Introducing the Survival Paradox: A Holistic Approach to Cancer and Chronic Disease

Dr. Isaac Eliaz: Today, I want to talk about the Survival Paradox and the survival protein, which is the hidden cause of cancer and chronic diseases. As many of my friends and colleagues say, my work has been the best-kept secret in town. With so many published papers, solid data, and decades of work, it’s time to share it with the world. I share it in my book, The Survival Paradox, which introduces a paradigm shift for people. You can find it on Amazon. It offers a new way of thinking about health, disease, and what you can do about it.

With that in mind, let’s get going. Since we have enough time, I’ll take my time and go in-depth. I’ll take everybody through a journey. Ryan, how much time do we want to leave for questions?

Ryan Sternagel: Take us on the journey, whatever that means—I want the journey.

Dr. Isaac Eliaz: A little bit about my background. I wish it was only 30 years, but it’s closer to 40 years of clinical practice and expertise and decades of training and teaching in mind-body medicine. I’ve spent 20 years going on solitary retreats in the mountains for two to three months a year. For 10 years, I did half-day meditation, and half-day work. I’m a medical doctor, but I also have a Master of Science in Chinese medicine, and I’m a licensed acupuncturist.

I’ve trained in multiple medical systems in parallel, a little different than a typical doctor who learns other methods. My thinking is multidimensional, which is expressed in my book The Survival Paradox. At the same time, while I can be a little holistic and esoteric, I’m also a researcher. I’ve published multiple peer-reviewed papers and received several NIH grants, including some very large ones. Specifically, I’ve researched the removal of galectin-3 via therapeutic apheresis as a treatment for sepsis and acute kidney injury; Eleven million people die from these conditions every year.

I also have a unique perspective on how to formulate different products, but at my core, I am a healer, and I love to share my heart with others.

Ryan Sternagel: That’s exactly what I said in the email about this. I don’t know too many people with as many peer-reviewed papers as you, who also lead week-long meditation retreats in their spare time.

[00:09:22] The Survival Paradox: Galectin-3 and Its Role in Cancer and Chronic Disease

Dr. Isaac Eliaz: What is the Survival Paradox? I think it’s very important because it contains a key to our healing. We are built to survive. Every cell in our body is built to survive. When we are in the womb, the survival drive helps the organs develop normally. When we are born, the survival drive is moved by the survival response.

Whenever we sense danger or are put in a dangerous situation, we respond with a survival response, and because it’s innate in us, it’s automatic. We don’t control it—it happens through the autonomic nervous system, specifically the sympathetic system. Once that gets activated, we get a sympathetic effect, but we can shift back to a normal state by moving to a parasympathetic state. You take a deep breath, relax, or go out in nature.

But as we remain in a stressful environment, especially when we start accumulating traumatic events—such as PTSD (and no one doesn’t have some level of PTSD)—our sympathetic response becomes disproportionate to the event. Why? Because it’s not driven by what’s happening at the moment; it’s driven by everything that’s happened to us in the past: toxins of all kinds, metabolic shifts, infections, physical traumas, emotional traumas, psychological traumas, and even problems at the genetic and epigenetic levels. These all accumulate and create an ongoing sympathetic response that drives anxiety and leads to fight, flight, or freeze reactions; We either react or we don’t move.

As we know, we can shift it back. The problem is, within minutes (probably within seconds) though we can’t measure it, there’s a biochemical trigger of survival proteins. The key one, which I’ve been researching for almost 30 years, and my major discovery, is that when galectin-3 is activated, it drives inflammation, fibrosis, immune dysregulation, and promotes cancer.

When you block galectin-3 with MCP (modified citrus pectin, also known as Pectosol), you reverse these effects. Galectin-3 is activated within minutes, but unlike the sympathetic system, where you can open and close the faucet, when galectin-3 is activated, the “water” (the biochemical effect) has already spilled out, affecting the body. This creates a cascade that drives inflammation and fibrosis (or hardening of tissues). From an immune perspective, it can cause a cytokine storm, which we’ve seen with COVID. It can also lead to mycotoxin damage, chronic illnesses, acute illnesses like sepsis, aging, and inflammation. And, big time, it drives cancer.

Why? Because cancer, by definition, is a survival response. What is a cancer cell? It’s a cell that decides not to go into apoptosis—a cell that has lost the recognition that it’s part of a community. Normally, a cell serves a purpose and then dissipates through apoptosis, but a cancer cell decides it needs to survive; What does it do? It creates its own environment. Cancer is the best example of an imbalanced survival response and immune dysfunction.

For example, we know that in the presence of galectin-3, PD-L1 inhibitors do not work. So we have a survival response that drives inflammation and organ degeneration, creating a loop driven by this protein called galectin-3. It’s a carbohydrate-binding protein. Now, what is this protein?

This protein binds to carbohydrates—not glucose, but carbohydrates like oligosaccharides, glycoproteins, and glycolipids, which are commonly oxidized lipids. Once galectin-3 attaches to these ligands, it creates a pentamer. Galectin-3 is produced in response to stress, toxins, illness, injury, and aging—everything we’ve talked about. It triggers inflammation, fibrosis, organ damage, cancer growth, and metastasis. Blocking galectin-3 has been shown to halt and even reverse cancer, along with other conditions.

[00:14:55] The Role of Galectin-3 in Cancer Metastasis and Immune Suppression

Dr. Isaac Eliaz: Now, what are these ligands? To understand galectin-3, think of it as a bus, taxi, or train. When there’s a problem, it immediately gets produced, rushes to the problem area, and carries these harmful ligands—like CEA, Mucin-1 (which drives primary cancer growth), MAC-1, CD98, and CD45. It blocks them and shuts down the immune response. Fibronectin, collagen, elastin, and laminin are involved as well, creating hyperviscosity, fibrosis, and damage to the extracellular matrix.

Cadherins and integrins (such as A3B1 integrins), make the cells sticky, promoting metastasis. VEGF receptors get blocked, leading to the growth of new blood vessels. NG2 creates inflammation in the brain—neuroinflammation—together with GAGs. Some medicines and strategies target each of these components, but galectin-3 is a primary driver. Blocking it affects all of these processes, which is why addressing galectin-3 is probably the most important thing you can do from a supplement point of view.

[00:16:22] The Widespread Impact of Galectin-3 on Chronic Diseases and Its Role in Inflammation

Dr. Isaac Eliaz: You can see from a paper published in 2018 that almost every disease is driven by galectin-3, including cancer. There’s great interest in its role in atherosclerosis, fibrosis, inflammation, and lung disease—especially relevant in COVID. There’s a lot of data on kidney disease, both chronic and acute, with much of my research focusing on acute kidney disease. It also affects liver fibrosis, including NASH (non-alcoholic steatohepatitis), which is part of the NAFLD (non-alcoholic fatty liver disease) epidemic affecting 100 million people in the United States. NAFLD increases mortality, among other effects.

As you can see, there’s significant interest in galectin-3, even if some of you haven’t heard of it. There are about 10,000 papers published on galectin-3 and over 80 papers specifically on Pectosol.

[00:17:16] Galectin-3’s Role in Cancer, Inflammation, and Systemic Disease Progression

Dr. Isaac Eliaz: What does galectin-3 do in cancer? Although this isn’t a cancer-exclusive talk, it’s relevant to all of us because it’s a universal mechanism.

Galectin-3 stimulates proliferation and inhibits apoptosis, which is obviously bad news for cancer, making it more aggressive. It also prevents macrophage apoptosis, which shuts down the immune response. If you put galectin-3 in a medium with T cells, no cytokines are excreted; Block galectin-3 and the cytokines are excreted again. Galectin-3 stimulates migration and promotes invasion, making it a major driver of metastasis. This was the main interest in blocking galectin-3 back in the early to mid-1990s when this research journey began.

Environmentally, it stimulates angiogenesis and inhibits immune surveillance, including the interference of NK cells, resulting in increased cancer survival. For example, in an AML (acute myeloid leukemia) model, galectin-3 affects the cell intracellularly—P53 gets downregulated, while BCL-2, an aggressive gene, gets upregulated.

When galectin-3 is excreted, mesenchymal cells and T cells get shut down, and they die. NK-mediated cytolysis is initiated, meaning NK cells die as well. The immune cells stop functioning. Intracellularly, there’s a loss of p53, repression of GAL3, induction of BCL2, RAS, and MYC, and inhibition of apoptosis.

Extracellularly, galectin-3 is excreted and forms lattices, as every pentamer attaches to another. This creates a microenvironment that promotes cell migration and angiogenesis and affects the immune system. Blocking CD45 causes T cell anergy and death, meaning the T cells become less effective.

For example, in a paper we published, we took normal volunteers and tested all medicinal mushrooms, but our MCP worked better. When we gave MCP, the number of NK cells increased tenfold over a concentration gradient, and the activity of each NK cell also increased by 50%. Without MCP, you have cell death and energy, making the cells less active and less beneficial.

What does galectin-3 do in circulation, systemically? It stimulates macrophages to become inflammatory, and inflammatory macrophages stimulate galectin-3 in return. Galectin-3 also stimulates extracellular matrix adhesion and fibroblast activity, which leads to myofibroblasts and fibrosis, such as scars in the heart and internal organs. Under stress and injury, fibroblasts excrete galectin-3, showing its central role.

Macrophages drive the cytokine storm, releasing TNF alpha, IL-4, IL-8, IL-6, and IL-1. This diagram is a few years old, but IL-6 is especially significant, and galectin-3 completely drives IL-6. When we block galectin-3, we completely shut down IL-6. IL-1b drives inflammation, tissue injury, and tissue fibrosis, leading to dysfunctional tissues. This is the inflammatory pathway, which parallels the “fight” quality of the sympathetic system—the biochemical equivalent of the flight-or-freeze response.

TGF-beta1 (transforming growth factor beta 1) also drives fibrosis and cancer. If we address galectin-3, we affect everything downstream.

Ryan Sternagel: It’s been a while since I’ve seen you present, Dr. Elias. I remember being amazed at how much galectin-3 was involved last time, but it’s still astounding. Maybe there have been more discoveries since then?

Dr. Isaac Eliaz: Yes, and it’s interesting. I have an NIH grant—a large one, $2 million—to study its effect on sepsis and acute kidney injury. That’s a major injury now, involving inflammation. You can see, again, how galectin-3 affects so many conditions.

How does it do this? It’s an upstream molecule. As we said before, trauma, injury, aging, infection, and stress drive it. It’s like opening the top of the waterfall, and everything flows down, creating inflammation, a cytokine storm, immune dysfunction, abnormal cell activity, and leading to biofilm and dysbiosis. You see this in Lyme disease patients, those with gluten sensitivity, dysbiosis, inflammatory gut diseases, organ failure, autoimmune diseases, and of course, sepsis, cancer, and fibrosis.

We often try to change things downstream, but it would be more effective to address it upstream, like shutting down the waterfall at the source. When you start addressing it here, you stop the waterfall. When you’re trying to address it downstream, you’re just collecting water with a bucket—not very efficient. How do we know this? In animal studies and humans, when a patient goes into sepsis—or in our animal studies—galectin-3 levels will double. In some cases, it will go up 50%, in others it will double or even triple. But interleukin-6, the cytokine storm, won’t just increase twofold—it will increase by a thousandfold or two thousandfold because it’s a downstream effect.

When we shut down galectin-3, for example in our sepsis studies, by blocking it with MCP, after 24 hours interleukin-6 levels return to normal. They don’t keep rising; The animals don’t get kidney damage, and they don’t die. In the ICU, a patient with sepsis, even without preexisting conditions, published in a critical care paper with great authors, their galectin-3 level at admission will determine who will die later.

For a patient with COVID coming to the emergency room—regardless of how severe the case of COVID—this was from 2020—their galectin-3 level at the time of admission will determine who will end up in the ICU and die.

[00:24:49] Blocking Galectin-3 with Modified Citrus Pectin: A Solution for Cancer and Chronic Disease

Dr. Isaac Eliaz: How do we block galectin-3? For those who know me, and for those who don’t, I usually don’t talk about a problem unless I have a solution. Otherwise, it just causes anxiety, and anxiety drives the survival response, which we don’t want. We block it using modified citrus pectin (MCP), the most researched and the only available galectin-3 blocker. It’s a complex polysaccharide fiber, a low-molecular-weight citrus pectin that’s easily absorbed by the GI tract, unlike regular pectin. It blocks galectin-3 for multiple oncological benefits.

It’s very important for oncological nutritional support, as it blocks cancer growth, disrupts metastasis, exposes cancer to the immune system, and eliminates heavy metals and other toxic compounds.

What MCP does is bind to the carbohydrate recognition domain (CRD) of galectin-3, dislodging the ligands, and causing the pentamer to fall apart. This allows the body to heal itself. Remember this principle, and you’ll understand it when I show you the results of our multicenter clinical trials.

[00:26:14] How Modified Citrus Pectin (MCP) Reactivates Immune Response Against Cancer

Ryan Sternagel: Sorry, Dr. Elias, I’m curious—what’s the mechanism by which MCP exposes cancer to the immune system?

Dr. Isaac Eliaz: Cancer uses galectin-3 to shut down the immune response, particularly by binding to CD45 and shutting down the immune system’s response. What MCP does is dislodge galectin-3 from CD45, causing the pentamer to fall apart into single monomers. Once that happens, the tissue is exposed, and immune function is reactivated; That’s how it works.

Ryan Sternagel: I like it. Someone was asking if we’ll have a replay, because this is a lot to absorb, and I agree—it’s all good stuff.

Dr. Isaac Eliaz: Let me tell you, I’m going slow today because we have a lot of time. I feel like I’m being redundant, but thank you for letting me know I’m not. I can speed up a bit if needed.

[00:27:18] The Unique Absorption and Systemic Benefits of Modified Citrus Pectin (MCP)

Dr. Isaac Eliaz: Regular pectin has benefits in the gut: It binds cholesterol and some toxins, but it’s high molecular weight—usually between 100 to 300. It has a high degree of esterification and does not get absorbed into the bloodstream. The specific modified citrus pectin (MCP) is modified to a very small size with a specific structure that is maintained, including its side chains.

I don’t want to tire you with too much chemistry, but it contains neutral sugars that stimulate the immune system, such as rhamnogalacturonan II, which is also found in immune-enhancing compounds in mistletoe. About 10% of Pectosol is made up of these compounds. By using a proprietary enzymatic purification process, we achieve systemic benefits, and it becomes highly absorbable into the bloodstream. We’ve demonstrated that our MCP gets absorbed into the bloodstream—it’s the only pectin that’s been shown to do so.

How does it work? By shutting down the whole cascade. When you block it at the top, you prevent the downstream damage. For example, in our cancer clinical trials on modified citrus pectin, we observed that one of the side effects is that people have more energy, less joint pain, and improved memory—because these underlying issues are being addressed. It’s nice to have a product where the side effects are positive!

[00:28:59] The Synergistic Role of Modified Citrus Pectin (MCP) in Cancer Treatment and Support

Dr. Isaac Eliaz: To summarize MCP’s role in cancer: It inhibits galectin-3 activity. It has a synergistic effect with chemotherapy, radiation, and different botanicals (all of this is published). It has a protective effect against post-radiation fibrosis, while also enhancing radiation therapy. It provides significant immune support and improves the quality of life at all stages of cancer. There are papers on this, and MCP shows potential benefits in conjunction with immunotherapies.

There’s a lot of interest in this from pharma, especially the manufacturers of PD-L1 inhibitors, who are investing in galectin-3 pharmaceuticals. MCP reduces tumor proliferation and angiogenesis (this was the initial interest), and it inhibits metastasis. I also discovered its role in removing heavy metals and toxins, as well as regulating inflammation and fibrosis.

You can see its dynamic applications. Chemotherapy drugs like cisplatin, doxorubicin, and dexamethasone, along with certain toxins and biological agents, have been shown to enhance the effects of MCP. It’s used in the treatment of chemo-resistant cancers and during radiation treatment, where it decreases side effects like treatment-induced inflammation and fibrosis. Because of its role in angiogenesis, it’s very important to take a high dose. The last thing you should take before going through cancer-related surgery or a biopsy is modified citrus pectin, as it can help prevent the spread of cancer cells based on this mechanism.

[00:30:58] Using Modified Citrus Pectin (MCP) to Reduce Cancer Spread Risks During Biopsy and Surgery

Ryan Sternagel: Dr. Elias, I want to underline that for everyone. I remember that being one of the things that stood out to me early on. This isn’t relevant to everyone, but there’s always talk about whether to biopsy or not, and the risk of cancer cells spreading when you do, but this is something you can take to mitigate that risk.

Dr. Isaac Eliaz: Definitely. In any case, it’s very important because we know MCP reduces and blocks angiogenesis and the inflammatory process, both of which are needed for metastasis. You should take 10 grams with the last water you can take before surgery and then take it again as soon as possible after surgery or a biopsy.

One of the studies we are planning is a study between biopsy and surgery in prostate cancer patients, to see if we can change the genetic expression of the tumor; This is a very important point.

[00:32:18] Clinical Success of Modified Citrus Pectin (MCP) in Slowing Cancer Growth and Enhancing Immune Response

Dr. Isaac Eliaz: This is a landmark paper. I presented this at ASCO GU in San Francisco, the annual meeting for genitourinary tumors. It was a poster session—if it was a drug, it would have been a plenary session—but it’s a natural product.

These are multicenter trials, 18 months, with 60 patients. These are patients whose prostate was removed either by surgery or radiation, and then their PSA levels—normally zero because there’s no prostate—started rising, confirmed three times. Hormone therapy was not given for more than three months, and their scans were negative.

The patients then go on six months of PMCP (pectosol-modified citrus pectin). They get monthly evaluations for toxicity, histamine, physical exams, and PSA, and are scanned every six months using PET PSMA (which finally came into the United States this year, though it’s been used in Europe and Israel for many years). This study took place in six different leading oncological centers in Israel. If after six months there’s no progression, patients continue for an additional 12 months.

This is the data after 18 months. We’ve finished the longer study, and it’s being submitted for publication and for the general ASCO meeting. In the first six months, 78% of the patients benefited, meaning the cancer growth slowed down (the PSA doubling time became longer). Out of this, 58% out of 78% stopped completely (indicating the cancer wasn’t growing), or decreased (indicating the cancer was shrinking). There were no side effects.

We had 46 patients who qualified for the 18-month period. Seven of them decided they didn’t want to come every month, but they bought the product and continued on their own. Out of the remaining 39, after 18 months, 90% had an improvement in cancer growth pace (meaning the cancer was growing slower), and 85% of the patients experienced either slower growth, no growth, or cancer shrinkage. There was no disease visible on scans—completely different from what you’d expect after 18 months of cancer recurrence.

Out of the 85%, 62% had decreased or stable PSA levels, with no significant side effects. The reason this is so significant, and why it’s different from studies using pomegranate, beta-sitosterol, or saw palmetto, is that those substances have phytoestrogens or phytosterols, which have a hormonal effect. Anything with a hormonal effect in hormone-induced cancers will help, but it will also change the hormonal expression of the tumor, eventually causing the cancer to become resistant. While there may be a great short-term benefit, the long-term benefit is questionable.

Here, with MCP, there’s no hormonal effect, no direct cytotoxic effect—it simply allows the body to deal with the cancer. How? We know this based on the mechanism and the numbers. Anyone who follows natural compounds in cancer will often see papers showing a new herb inhibiting 90% of cancer growth in vitro (in a Petri dish), and then it helps 70% of animals, but when it’s tested on humans, it helps 0%. That’s a common story.

Here, in the Petri dish, MCP helped less than 50% of the time. But in the clinic, it helped 90% of the patients; Unheard of. No other example like this. Why? Because MCP allowed the body to make the change. Why? Because, as I showed you, it’s an upstream regulator of trouble that we’ve eliminated. The body has the power to heal itself. Remember what we talked about in the beginning? The body has the power to heal, and the immune system is an expression of that power. When we discovered that galectin-3 shuts down the immune system, and MCP can improve it, it supported this idea.

[00:37:13] The Wide-Ranging Health Benefits of Modified Citrus Pectin (MCP) Beyond Cancer Treatment

Ryan Sternagel: You hear all the time about something working so well in the Petri dish, but then when you take it into actual humans, it’s a whole different story; Whether it’s a natural compound or a drug, the same thing happens to both. But I’ve never heard of something working better in humans.

Dr. Isaac Eliaz: Exactly. That’s why I say it’s essential for everyone to take it, because galectin-3 levels go up as we age, and eventually it will affect us. It doesn’t matter how high your levels are—MCP inhibits galectin-3, blocking inflammation and fibrosis. It also fights cancer growth and metastasis. All of this is published, of course. MCP supports cardiovascular and kidney health, and there are many papers on that. It detoxifies heavy metals—I’m the one who published these papers. It also modulates immune function and synergizes with other therapies.

[00:38:15] Dosage Recommendations for Modified Citrus Pectin (MCP) Based on Health Needs

Dr. Isaac Eliaz: How to take it? You can take it in powder or capsule form. Chewables are available for children or people taking lower doses. If you’re very healthy, under 40, and have no health issues, you can take just one scoop a day—about five grams or six capsules.

If you’re more interested in immune support, detox, or supporting your inflammatory and cardiovascular responses, you should take five grams twice a day. That’s recommended for anyone who is relatively healthy.

If you’re dealing with a health issue—especially oncology support or tissue repair—you should take three servings per day. You can split them into one-and-a-half scoops twice a day, taken 10 to 15 minutes before food or an hour after. You can take it at the beginning and end of the day, and it’s fine to take it with other supplements.

This is a big part of my life’s work. I’ve done a few things in parallel, but I’ve spent about 28 years involved with MCP and galectin-3 research.

[00:39:30] Honokiol: A Powerful Compound for Oncology and Neurological Health

Dr. Isaac Eliaz: Another amazing compound is honokiol. It’s an undervalued compound. I introduced it to many people in the United States over the last decade. Unfortunately, I was the only person in the world, along with a compounding pharmacy, who was able to create honokiol intravenously and give it to cancer patients—with amazing results.

I can share this now because I can’t do it anymore, but I published the cases in Integrative Cancer Therapies as a paper. It was done under study and informed consent, but due to the political environment, I didn’t talk about it until I was no longer able to continue the treatment.

Ryan Sternagel: Good old political environment.

Dr. Isaac Eliaz: Exactly. Honokiol is a powerful, versatile extract for oncology and neurological health. It’s a purified phenol from magnolia bark that crosses the blood-brain barrier, which is very important. It also crosses the blood barrier in general. It has a unique property, which I’ll explain in the next slide—it’s the only slide I’ll go deep into biochemistry because I love it.

Honokiol regulates the inflammatory response in the brain. It shifts the brain from an excitatory, hyperglutamate-driven state to a GABA-inhibitory, neuroprotective phase. It’s a powerful antioxidant and provides anti-inflammatory support to normal cells. It also regulates the cell cycle and promotes apoptosis in abnormal cells, based on the recognition of certain active pathways within the cell. It’s incredible.

It promotes restful sleep at lower doses, reduces anxiety, and synergizes with oncology protocols. There are many papers showing its synergy with biological agents, immunotherapy, hormonal therapy, and chemotherapy.

[00:41:40] Honokiol’s Role in Cellular Energy Regulation and Its Synergy with MCP in Cancer Cells

Dr. Isaac Eliaz: How does it work? In a normal cell, glucose enters through glucose transporters. Then, glycolysis converts it to pyruvate. Pyruvate dehydrogenase works efficiently, producing 36 ATP (adenosine triphosphate) from one glucose molecule in the mitochondria. This is possible because pyruvate dehydrogenase kinase (PDK), the enzyme that blocks the entry and use of pyruvate in the Krebs cycle is inhibited.

It’s blocked because the cell is in a state of safety; it’s not under survival drive. We’re going back to the beginning—how do we know? Hypoxia-inducing factor (HIF), which signals that the cell doesn’t have enough oxygen and is in crisis, is blocked. mTOR1, which many of you have heard about, is also blocked. Why? Because the cell is producing energy efficiently. AMP kinase (AMPK) is activated, insulin receptors are active, and glucose is coming in. P53, the tumor suppressor gene, is active, and PTEN suppresses PI3K (which many drugs target), AKT, and mTOR1.

In this healthy cell, honokiol acts as an antioxidant, helping to clear lactate. One of the reasons this cell stays normal is because galectin-3 is neutralized. When you take MCP, it switches the environment outside the cell from abnormal to normal, which also affects the intracellular environment. When you take honokiol alongside MCP, they work synergistically—one works intracellularly, the other extracellularly. This is my discovery, and I have patents on it all over the world.

In a cancer cell, however, it’s a different story. Glucose doesn’t work properly. Glycolysis and pyruvate production are shut down because PDK is activated, as well as mTOR1, HIF, MYC, AKT, and PI3K. Meanwhile, P53 is suppressed, and the cell goes into survival mode—this is what we call the Warburg effect, where cancer cells use aerobic glycolysis. Despite oxygen being available, the cell doesn’t use it to produce energy efficiently.

A dysregulated cell membrane leads to energy production that’s 100 times faster but far less efficient. Instead of producing 36 ATP molecules per glucose, cancer cells only produce 2 ATPs—just 5% efficiency. But because they can produce energy 100 times faster, they end up using 2,000 times more glucose. This is the principle behind PET-CT scans: the more aggressive the cancer, the more glucose it takes, and the higher the SUV (standardized uptake value) on the scan.

[00:45:23] Honokiol’s Adaptive Role in Cancer Treatment: Regulating Cellular Metabolism and Enhancing Therapies

Dr. Isaac Eliaz: We want to normalize this mechanism, so Honokiol blocks mTOR1 and enhances AMPK, as do berberine, metformin, and MCP from the outside. Honokiol also promotes an oxidative attack on cancer cells. It works well with immunotherapy, chemotherapy, and radiation therapy.

The beauty of honokiol is that it adapts based on the cell’s behavior—it’s like a community organizer, keeping the good stuff and cleansing the bad.

[00:46:10] Synergy of Honokiol and MCP: Supporting Oncology, Inflammation, and Neurological Health

Dr. Isaac Eliaz: We want to combine honokiol and MCP for cellular health, oncology support, and especially for inflammation and cardiovascular support. I hope to soon combine them into one product with different ratios, to make it easier for people. But for now, I’ll show you how to combine them.

There’s research showing the synergy between the two, both for oncological support and for anti-inflammatory, and antioxidant effects. We published a paper on this: MCP works outside the cell, while honokiol works inside the cell. It’s a powerful, clinically recommended combination for oncology support, neurological support (especially neuroinflammatory conditions), and health inflammation.

Honokiol, specifically, crosses the blood-brain barrier, just as MCP protects the gut and works outside the cell. Galectin-3, however, disrupts the blood-brain barrier and activates glial cells—the macrophages and immune cleaning cells of the brain—leading to chronic inflammation. Alzheimer’s plaques contain 10 times more galectin-3 than normal tissue, which is why this combination is great for addressing neuroinflammation, memory, and mental function.

[00:47:44] Dosage Guidelines for Honokiol and MCP: Supporting Sleep, Anxiety, Inflammation, and Cancer

Dr. Isaac Eliaz: How to take it? You build up the dose of MCP gradually to one and a half scoops, twice a day. For honokiol, the dosage depends on your intended use. If you’re using it for sleep, take one capsule of Honopure (250 mg) before bedtime. For anxiety, take one with dinner, one before bedtime, and one with breakfast, or twice a day.

For inflammation, take two capsules twice a day. For cancer, you can build up to 12 capsules daily, gradually increasing the dose. Honokiol has neuroprotective properties, so you might feel a bit drowsy—“stoned” in a clear, relaxed way—but most people tolerate it well; It also helps with sleep.

For antioxidant support, take two capsules twice a day with food, and for cancer, build up to four capsules, three times a day.

The main side effect is diarrhea, similar to what some people experience with metformin or berberine. You can manage this by gradually increasing the dose of both honokiol and MCP. This combination is an effective way to manage your survival response.

[00:49:01] Transforming the Survival Drive: Galectin-3 Blockers, Detox, and Open-Heart Meditation for Healing

Dr. Isaac Eliaz: How do we transform our survival drive to work for us, rather than against us? By addressing galectin-3 with proven blockers, practicing gentle detoxification (very important), and incorporating regular meditation. I’ve done a lot of work on removing pesticides, especially glyphosates. We’re running a preliminary clinical trial with excellent results and are now expanding it to 30 people with a product called GlyphoDetox.

Meditation goes even deeper than this. What I call “open heart medicine” involves connecting with the heart, where true transformation occurs. In everyday life, we live in a state of reactivity, with a short attention span, moving from one thought to another without noticing the gaps in between. When we slow down and breathe—basic mindfulness, which is only the first step of meditation—we start to create space between our thoughts.

The easiest way to do this is to focus on the space between passive exhalation and inhalation, and let go. As we create space, emotions, memories, and insights surface. Deeper layers of ourselves that we weren’t aware of begin to come up. This is where trauma and toxins may arise, and how we respond depends on the depth of our meditation.

This gives us the opportunity for real healing. As long as we don’t hold on to these thoughts, solidify them, or make them fixed and unchangeable, they won’t stop us. Because beneath each layer, there’s always another, like a flowing river. As long as we accept and let go, we shift from an ego-driven, survival-focused reactivity to an accepting, transformative, open-heart state of love, compassion, and healing.

Why is this important? Every cell in our body takes in nourishment and releases toxins—this is survival. The only organ in the body that thrives by taking in what others discard and transforming it into something beneficial is the heart. The heart functions differently from the rest of the body. As it nourishes itself, it also nourishes others at the same time. After the heart has completed its selfless work of transforming and purifying blood, it relaxes and nourishes itself through the coronary arteries.

That’s a beautiful physiological example of self-love as part of loving others. It’s very different from narcissistic love. The heart is the only organ that nourishes itself after it has completed its work. We are built to do this—that’s the divine within us. It’s a quality we came into this world to work with, and it has amazing healing power.

I’m giving you a little insight for those who’ve stayed with me so far. With this in mind, I think this is the last slide, so I’m going to turn it off and see Ryan on the big screen. I’m ready for questions.

Ryan Sternagel: It was great. I think with these webinars, people sometimes start to drop off, but I’m pretty sure the numbers have gone up as we’ve gone along. You’re captivating, Dr. Elias—no worries there.

[00:54:12] Supporting Chronic Lymphocytic Leukemia (CLL) with MCP, Honokiol, and Detox Strategies

Ryan Sternagel: People are asking, what do you suggest for a CLL (Chronic Lymphocytic Leukemia) diagnosis?

Dr. Isaac Eliaz: CLL is very much driven by galectin-3, so Pectosol is important as nutritional support, as is honokiol. You may see dramatic drops in counts, but you’ll also need to monitor your hemoglobin if you take a lot of honokiol. CLL and blood cancers, in general, are very affected by toxins, especially pesticides—particularly glyphosate. Detox mechanisms are essential, and you can read more about GlyphoDetox.

Glyphosate (Roundup) is a global poison, and some countries are finally saying no to it. It has numerous side effects and causes a lot of damage. One part of this is that glyphosate mimics gluten sensitivity. You can have gluten sensitivity with anti-gliadin, along with all the symptoms—dysbiosis, leaky gut, digestive problems that can lead to SIBO, and brain fog.

What’s interesting is that you can go on vacation to Italy, eat pasta and pizza, and suddenly your gluten sensitivity seems gone; This is universal. You say, “Oh my god, my gluten sensitivity is cured!” But sure enough, when you return to the United States, it comes back. Why? Because in Italy, GMO is illegal, and glyphosate is illegal. Glyphosate induces a gluten-sensitivity-like effect, which is why we have an epidemic of gluten sensitivity in this country.

Pesticides also affect kidney function and lead to neuroinflammation, which contributes to conditions like Alzheimer’s, ADHD, and autism.

[00:56:35] MCP and Honokiol Dosage Guidelines for Children and Support for Cancers Like CLL and Multiple Myeloma

Ryan Sternagel: Tracy had asked this earlier: “Do you have any guidelines or guidance on dosing for children?” Tracy has a six-year-old.

Dr. Isaac Eliaz: EcoDetox and GlyphoDetox can be taken with MCP—it’s not a problem. Ryan already gave you the link where you can find more information about the products. I’m not involved with the company anymore. I founded it, but I’m not involved in the day-to-day operations. That’s why I wasn’t involved in this process, but I’m glad it was taken care of.

Pectosol is very safe. There are no studies on pregnant or lactating women, so I recommend caution, though it’s probably fine. We published an impressive paper in China on children with lead toxicity using our MCP. These children used 15 grams a day, and some were under the age of five (though we only published data on kids over five). For children under 50 pounds, we recommend one scoop (five grams) a day. For children under 25 pounds, perhaps half a scoop. For children over 50-60 pounds, they can take five grams twice a day. By 80 pounds, they can take a full dose, even as low as 50 pounds in some cases.

Honokiol is also safe for children. I’ve had experience using it with children, particularly for neurological tumors. However, the capsules are too bitter to open, so they need to be able to swallow them. I’ve treated children with spinal tumors and other tumors intravenously.

We also published data showing that Pectosol and Honopure (honokiol) work synergistically with letrozole, as part of our BreastDefend product, as well as with tamoxifen for oncological support. Similar dosing can be used for conditions like non-Hodgkin lymphoma. In fact, multiple myeloma was the initial cancer that modified citrus pectin (MCP) was tested for. It was close to being approved by a pharmaceutical company (under the name GS 100) in the mid-1990s, but they had a manufacturing issue, and in the drug industry, if something changes, you have to start all over again, so the company eventually folded financially. Still, modified citrus pectin is very important for multiple myeloma.

[00:59:23] Supporting Neurodegenerative Diseases with MCP, Honokiol, GlyphoDetox, and Additional Therapies

Ryan Sternagel: You had mentioned neurological conditions, Dr. Eliaz. There were a few questions about Parkinson’s and neurodegenerative diseases in general, especially in response to the information about crossing the blood-brain barrier and helping with inflammation in the brain. Could you speak more on that?

Dr. Isaac Eliaz: Wow, of course. That’s a great question. It doesn’t break a fast, by the way—there’s no caloric value. For neurodegenerative diseases, which are inflammatory diseases, the basic protocol is to take modified citrus pectin (Pectosol), honokiol, and GlyphoDetox. These are the three key products. If you can do more, I recommend adding a pre/probiotic to support the gut and also adding Padma Basic, a unique Tibetan medicine-based herbal formula. Padma Basic has been an approved drug in Europe for almost 60 years for circulation. There’s a very impressive double-blind study published on Pedma Basic’s effects in multiple sclerosis; That would be an additional recommendation.

The formula called BreastDefend—we have four or five papers published on it—doesn’t directly help with the MTHFR mutation, but it supports detoxification by reducing inflammation.

One interesting thing about modified citrus pectin is that Lyme disease patients do well with it because it helps stabilize the gut.

[01:01:24] Tips for Properly Dissolving MCP and Combining It with Other Supplements

Dr. Isaac Eliaz: Great question about how to dissolve it! You can definitely put it in a smoothie, but here’s a trick: we used to have glass shaker bottles, but you can use any regular glass bottle that you can close. Let’s say you’re preparing for the day with three scoops, or you’re taking two scoops at once, or even just one and a half scoops.

First, put very little water—about an inch high. Then add another inch of hot water (not boiling, because the first layer is cold water). Don’t touch it for two or three minutes. The particles are very small, so you want the water to absorb them. Once it’s absorbed, shake it well and it will completely dissolve. Then add more water, shake it again, and you’re ready to drink.

If you’re using MycoPhyto (the mushroom immune support formula), or our pre/probiotic products like EcoSleep or EcoProbiotic, you can mix them together at the end. You can even mix in liquid fulvic acid with minerals. The key is to add a little regular water and a little hot water to the Pectosol, let it sit for a few minutes, shake it, and it will completely dissolve—no problem.

One and a half scoops is equivalent to nine capsules. If you’re trying the powder but find the lime flavor too strong, you can mix half lime and half regular until you find a balance that works for you.

The Tibetan formula is called Pedma Basic, and it has many published papers. In Europe, it’s known as Pedma 28.

[01:03:27] Timing MCP and Other Supplements with Thyroid Medication

Dr. Isaac Eliaz: Another great question—I like to take my thyroid medication (MP Thyroid) on its own. I take it first thing in the morning, wait a few minutes, and then start taking everything else. Things dissolve pretty quickly after a night when your stomach is empty. You can take it with the zeolite detox—there’s no problem there.

[01:04:00] Galectin-3 Testing: Availability, Interpretation, and Its Role as a Health Biomarker

Ryan Sternagel: There was a question earlier about testing for galectin-3, Dr. Eliaz.

Dr. Isaac Eliaz: That’s a great question. Galectin-3 testing is a good topic for a few minutes. Galectin-3 is a highly available, FDA-approved test (since 2011) offered by every major lab—Quest, LabCorp, Cleveland Heart Lab, Boston Heart Lab, and others. It’s a cheap test, usually covered by insurance. If it’s not covered, labs can overcharge, as they do with many tests. Insurance might pay $20, the doctor pays $100, and the patient ends up paying $300. They don’t let the patient have the doctor’s price—just part of the medical system politics.

That said, you don’t take MCP based on your galectin-3 levels. Due to genetic predisposition and something called MMP-9 (myeloproteinases), people have different ratios of monomers to pentamers, which can affect blood levels. You should take MCP based on your health condition. If you have health issues, as I showed in the slides, you go to a higher dose. If you’re healthy, you can take a lower dose.

Why would you check galectin-3 levels? One reason is that you might find you’re healthy but have high levels of galectin-3. This could be due to scars in the body that haven’t healed—whether from surgery, a cut, internal organ scars, or even emotional scars—or because of heavy metals or toxin loads. If your galectin-3 is elevated, you may need to take a higher dose of MCP.

What MCP does is block galectin-3, not remove it. If you notice that your health condition correlates with galectin-3 levels—such as someone with cancer where the cancer is spreading and galectin-3 levels go up, and then after treatment, the cancer volume goes down and galectin-3 decreases—then it becomes a good biomarker. You can follow galectin-3 as a marker of progress.

Galectin-3 is also a good biomarker to predict diabetes in the future. It was supposed to be FDA-approved for this, but the company that developed the assay went out of business before it could happen.

What are normal levels of galectin-3? They are much lower than what the lab forms typically show. The test was approved for patients with heart failure, and many of those patients also have kidney failure, which means galectin-3 levels are higher due to poor excretion. The labs often say under 17.8 is normal, but actually, under 11 is normal. Even levels above 12 are a bit high, and above 14 is more concerning. By the time you get to 16, it’s something to watch.

There was a large study—almost 9,000 people—the Birmingham Offspring Study, with 8,000 participants. They found that the bottom 40% of galectin-3 levels were around 10.9, while the top 20% of participants had levels of 15.6. Over 10 or 11 years, the top 20% had triple the mortality rate compared to the bottom 40%. That’s how dramatic the difference is.

[01:08:04] Low Galectin-3 Levels: Rare Cases in Cancer and the Impact on Fibrosis and Immune Response

Ryan Sternagel: I can feel more questions coming in, but Dr. Eliaz, there was another interesting one asking if you ever see low or no galectin-3 levels in cancer patients.

Dr. Isaac Eliaz: Great question. You don’t see any galectin-3 in anybody because it’s always excreted. Sometimes, you may see low galectin-3 levels, but that’s not common in cancer. You might see it in conditions like Lyme disease, where galectin-3 is sequestered in the tissue, and the body struggles to perform normal repairs. When galectin-3 is low, the body is freezing up and producing a lot of fibrosis. In such cases, TGF beta-1 (transforming growth factor) can be highly elevated—20,000 or 30,000, when the normal level is under 6.

When you give them MCP, galectin-3 levels can rise from abnormally low (around 4) to 7 or 8, which is still within the normal low range. At the same time, TGF beta-1 levels drop from 30,000 or 20,000 down to normal levels or around 10,000. This helps balance the immune response. However, in general, cancer patients typically have normal or elevated galectin-3 levels.

From an epidemiological perspective, when looking at populations with significant diseases—whether it’s kidney disease, heart disease, lung disease, liver disease, cancer, neurological diseases like Alzheimer’s or strokes, or autoimmune diseases—the higher the galectin-3 levels in the population, the more severe the disease.

Ryan Sternagel: Very good. Interesting point.

[01:09:45] Using MCP for Smoldering Multiple Myeloma and Its Long-Term Benefits in Detoxification and Immune Support

Dr. Isaac Eliaz: Regarding smoldering multiple myeloma, that’s a treatable condition. Full-dose MCP, absolutely—15 grams a day for smoldering multiple myeloma. I have a lot of experience with it. There’s no concern about taking MCP if your detox pathways are blocked. It doesn’t detoxify through the typical detox pathways; instead, it binds to toxins and reduces the inflammatory response, allowing you to detoxify more effectively.

For people who have difficulty detoxifying, MCP can make a significant difference. In the long term, MCP helps support the immune system by removing suppressive compounds that interfere with the immune response and by eliminating toxins that continuously affect the immune system.

We are interested in lupus. We’ve done some studies on it, and some of our colleagues have also worked on it. MCP has also been a filter for leukemia. Now, I want to emphasize that MCP is not a cure—it’s one more compound you use in combination with other treatments.

For example, today I presented data on biochemical relapse in prostate cancer. We use multiple methods and treatments, not just one. Interestingly, conventional oncologists in Israel, after seeing the results of MCP, started giving it to their patients with metastatic prostate cancer. We’re now collecting that data, and it’s very impressive. We hope to publish it in the next year.

The beauty of MCP is its long-term beneficial effect.

[01:12:00] The Power of Positive Language and Long-Term Integrative Support in Cancer Remission

Dr. Isaac Eliaz: MCP can reduce C-reactive protein (CRP) if the inflammation is reduced. It doesn’t bind CRP directly, but it reduces it by addressing the inflammatory process.

If you’re in remission from multiple myeloma, MCP (15 grams) is a must. The longer you use it, the longer you should celebrate because you’re in remission. And very importantly, when someone says “remission,” it often implies they expect the cancer to come back. Don’t use that vocabulary—you’re solidifying a negative statement.

I’ve worked with quite a few multiple myeloma patients, including those who’ve had stem cell or CAR T-cell treatments. With stem cells, people often expect the treatment to work for three years or two years. Even some very evolved individuals are so caught up in this mindset that they say, “Let’s do these treatments until it comes back.” It takes a lot of work to change that way of thinking.

For some of these people, the only difference was that I got the remission to last seven years instead of three. What happened during those extra four years? CAR T-cell therapy became available, and now they’re cured—when otherwise, they might have been dead. One of the keys in integrative oncology isn’t necessarily finding the “amazing cure,” but rather, can you stretch things out? Can you buy a few more weeks, a few more months, another year and a half, all with better quality of life?

If you have five or six different treatment options, and each one gives you an extra six months, that’s three more years of good-quality life that most drugs won’t give you. And guess what? For example, in HER2-positive breast cancer, there have been so many new treatments in the last three or four years. You give someone a few more years, and a whole new set of treatments becomes available.

If you can create a bigger window between treatments, the probability of resistance to the same treatment goes down. That’s a very important principle to understand. People often ask me, especially the skeptics, “Can you give me some miracle cases?” I tell them, “Of course, but I’m not interested in showing you miracle cases. You’re welcome to come talk to anyone in the IV room—everyone will tell you they’re doing better than expected.” That’s what we care about, not just that one out of a hundred gets better. What happens to the other 99? Regular oncology has its miracles too. But we’re interested in improving the odds for everyone. To beat the odds, we have to think creatively, integratively, and in a non-restrictive way. We have to keep moving forward, especially in cancer, because cancer doesn’t take a break. Therefore, we don’t get the privilege of taking a break—we need to figure out how to work with it wisely.

Ryan Sternagel: I like that you point that out, Dr. Eliaz. I never liked it when people would say my son had cancer. I’d always correct them and say, “He’s going through cancer,” or “He’s healing from cancer,” or something like that. And on the other side, I don’t like it when people say he’s “in remission.” No, he’s good. He’s healthy. I’ve never liked that term either.

Dr. Isaac Eliaz: These terms are powerful. When doctors use them, their minds—though they’re good people—are based on expectations and studies that say, “Yes, they’re in this two-year, three-year, four-year window.” Some cases, like in children’s leukemias, do result in lifelong cures. But we must remember not to buy into the mental restrictions of those around us, including doctors. This doesn’t mean we disconnect from reality, but it gives rise to science-based optimism. And optimism gives rise to gratitude, happiness, love, and compassion. All of these change the outcome of every disease, and they’re disrupted when we’re in survival mode.

That’s the essence of the Survival Paradox.

[01:16:59] MCP for Hormone-Positive Breast Cancer and Its Synergy with Hormonal Therapies

Ryan Sternagel: We had a question about hormone-positive breast cancer in relation to Pectosol.

Dr. Isaac Eliaz: For hormone-positive cancer, it depends if the person is on hormonal therapy, and which type. Pectosol is a no-brainer—it will be synergistic. We have studies showing that BreastDefend, as an oncological nutritional support, works synergistically with hormonal therapy. It can be used together.

MCP will reduce arsenic because it’s positively charged—definitely.

Ryan Sternagel: That’s what I love! We always look for supplements or products with multiple mechanisms of action, where you’re getting multiple benefits. You’ve laid out all the science and pathways, but then it’s also an amazing binder that mops up heavy metals; That’s cool.

Dr. Isaac Eliaz: Lots of questions! Every time I answer one, I seem to get ten more. Maybe I shouldn’t answer any more questions!

[01:18:30] Combining Pectosol with Other Supplements: No Interference with Mineral Levels

Ryan Sternagel: This is an interesting question—whether to take Pectosol with other supplements. You mentioned you can, but the binding properties won’t interfere, right?

Dr. Isaac Eliaz: Yes, it gets absorbed, so it’s not a problem. It doesn’t lower mineral levels. By the way, you can use honokiol with hormone-positive breast cancer, of course.

[01:18:58] Supporting Vasculitis with Pectosol, Honokiol, and Detoxification

Dr. Isaac Eliaz: There was also a question about vasculitis. So, for vasculitis, you definitely want to use Pectosol. You also want to use honokiol and Pedma Basic, and you need to focus on removing pesticides and toxins in general. If vasculitis is related to autoimmunity, it’s a bit more complex, but again, Pectosol addresses a fundamental imbalanced inflammatory mechanism. Anything inflammatory can benefit from Pectosol, and yes, you can definitely take it with Revlimid—it’s not a problem.

[01:19:53] Post-Radiation Support for Throat Cancer: Preventing Scarring and Enhancing Treatment with MCP and Honokiol

Dr. Isaac Eliaz: Another question about the effects of targeted radiation for throat cancer. It’s so important to prevent scarring, which is driven by galectin-3. Your most important supplement post-radiation is modified citrus pectin. When doing supplements during radiation, you take certain ones during treatment and others afterward. Remember, radiation keeps working for another three weeks post-treatment—it works for years, but is active for three weeks. You need to keep oxidative stress in check.

One supplement that enhances radiation therapy is honokiol. In general, I see a lot of cancer patients taking modified citrus pectin, honokiol, and artemisinin—specifically Artemact, a product that’s three times stronger than regular artemisinin because it combines artemisinin, regular artemisia, and artemisia extract. You can also use supplements like Boswellia, quercetin, curcumin, and melatonin; These are very basic compounds for enhancing radiation while preventing inflammatory damage. It’s important to differentiate between antioxidants and protection from inflammation. Inflamed tissue is hypoxic, and when tissue is hypoxic, radiation doesn’t work well. Radiation requires oxygen to create oxidative stress. Using these compounds will improve radiation effectiveness.

Once the radiation phase is over, you can use tocotrienols and the full family of vitamin E (all forms together, but not succinate). You can also use Pedma Basic and a drug called pentoxifylline (400 mg, three times a day) to improve circulation.

For people with significant radiation issues like scarring and inflammation, in the clinic, I’m a pioneer in a process called therapeutic apheresis. It’s similar to dialysis but more advanced. We separate plasma from the cells using a special filter to remove oxidized lipids, growth factors, and some heavy metals. This dramatically reduces inflammation and helps with post-radiation healing. Radiation has a supportive phase for about three weeks after treatment, and then there’s a longer phase where you work to prevent side effects that can last up to three years—more intense in the first six months, and then less so.

[01:23:10] PQQ and Shilajit: Supporting Gut Health, Detox, and Mitochondrial Function

Dr. Isaac Eliaz: You can also take PQQ (pyrroloquinoline quinone), which is great. PQQ is present in Shilajit and the fulvic acid complex, which is an incredible compound from Ayurvedic medicine. It’s filtered through mountains over tens of millions of years. It’s a key ingredient in my product GlyphoDetox because it helps stabilize the gut lining, binds to glyphosate, reduces neuroinflammation, and supports metabolic and mitochondrial function.

[01:23:50] MCP as Nutritional Support for Lyme Disease: Enhancing Antibiotic Effectiveness and Reducing Inflammation

Ryan Sternagel: I think the questions are going to keep coming the longer we go. Can we talk a little about Lyme?

Dr. Isaac Eliaz: I cannot emphasize enough how important modified citrus pectin is as nutritional support for Lyme patients. You don’t get the aggravation that you’d get with regular binders because it reduces inflammation. There are studies showing that our modified citrus pectin dramatically enhances the antibiotic effects against Staphylococcus aureus and other bacteria. It balances the biofilm, acts as a prebiotic, and helps antibiotics work better—very important for Lyme disease.

[01:24:42] Using Artemisinin for Prostate Cancer: Dosage Guidelines and Liver Health Monitoring

Dr. Isaac Eliaz: As for using artemisinin for prostate cancer, it can be used, but you have to monitor it carefully. The key thing with artemisinin is that you want to check liver enzymes because it can cause chemical hepatitis, which is reversible. However, when you use artemisia itself, it has hepatoprotective qualities—nature is smart! The herb contains compounds that are powerful but also protect the liver. You can go up to 400 mg twice a day, but you can also do as little as 200 mg. Typically, you take it for four days and then three days off, or seven days on and seven days off. You don’t use it continuously.

[01:25:48] Supporting Kidney Health and Managing Blood in Urine Post-Injury with MCP: Dosage Guidelines for Kidney Function

Ryan Sternagel: Any thoughts on this question about blood in the urine and kidney cysts from a fall, Dr. Eliaz?

Dr. Isaac Eliaz: I do a lot of work with the kidneys. Someone asked about PKD (polycystic kidney disease). There are different kinds of PKD—some are juvenile, and some are adult-onset. Galectin-3 is a driver of PKD, and addressing it can help as long as the disease isn’t very advanced. Once it becomes advanced, there’s often no more healthy tissue left to work with, like in regular kidney disease.

For blood in the urine from an injury, there’s likely some inflammation involved, and in this case, Pectosol will be very helpful. However, you have to watch the dosages; If you have severe kidney failure, especially if you’re close to dialysis and your eGFR is under 15, you should take only five grams of Pectosol. If your eGFR is under 30, take only 10 grams. If it’s above 30, you can take a normal dose.

[01:27:09] Supporting Glioblastoma Treatment with Honokiol, MCP, and Detoxification

Dr. Isaac Eliaz: Let’s talk about glioblastoma, because I was about to start a big study in Israel, and then COVID came. The two essential supplements for glioblastoma are honokiol and Pectosol. They work synergistically for multiple reasons, and you can take them alongside radiation and chemotherapy. That is, five out of 28 days—it’s not a problem.

Glioblastoma is tricky, but you can improve the outcome. I’ve had some cases with dramatic long-term survival. You can prolong life and improve quality. You also want to look at detoxification options.

[01:28:00] Managing Mold Toxicity with MCP, GlyphoDetox, and Gradual Detoxification

Dr. Isaac Eliaz: I want to say one more thing about black mold. Mold toxins are a huge issue—huge. Pectosol is essential for dealing with mold toxins. It’s part of what I call the Detox Rescue Kit, which includes Pectosol and GlyphoDetox. Some mold toxin patients are very sensitive, so you have to build up the Pectosol dose gradually until you reach 15 grams. Start with only two and a half grams. Also, with GlyphoDetox, start with one capsule and work your way up to four.

If you experience side effects, don’t stop. One of the issues with mold toxicity and mast cell activation is there’s a built-in anticipation of reactions—justified anticipation because of past trauma. As I mentioned earlier in the presentation, a traumatic event creates an exaggerated response. Anything is possible—you could take the next dose and not react at all. But if our mind is already “allergic” to something, our body will respond accordingly. The nervous system and neurotransmitters drive this response.

For severe mold toxicity cases, therapeutic apheresis may be necessary.

Thank you, everybody. I was honored, and thank you for sticking with me. It was fun. I love answering questions—it’s my favorite thing.

Ryan Sternagel: This was great. I’m excited to be back doing webinars. We had a lot of fun with these last year. Expect one a week going forward. Thank you, thank you—this is the best part of my week. All right, Dr. Eliaz, see you next time. See you, everybody!